This study was carried out to investigate the effects of Solignum, extracts of Aguwa (Euphorbia balsamifera) and Gamalin against termites on Triplochiton scleroxylon (Obeche) and Isoberlinia doka (Doka) wood species. Non-pressure method (brushing) was used in applying the preservatives. The treatments combination consisted of four treatments, i.e. one local bio-insecticide Aguwa extract (LBI), two conventional insecticide (Solignum and Gamalin) and a control replicated five times and laid out in a randomized complete block design (RCBD), the wood was exposed to termite mound to test the efficacy of the preservatives on the wood species. Data obtained were analyzed using Analysis of Variance (ANOVA) at 5% probability level. The results showed that there were significant difference between the two species (i.e. Obeche and Doka) (p<0.05) and between treatment. Solignum and LBI has the lowest percentage weight loss of 107.80g and 104.62g with best density of 0.30g/m3 and 0.33g/m3 and the control sample have the highest percentage weight loss of 116.64g with lowest density of 0.28g/m3 on obeche, while on Doka, Solignum and LBI has the lowest percentage weight loss of 185.80g with best density of 0.38g/m3. The control sample had the highest percentage weight loss of 213.48g with highest density of 0.43g/m3. It can therefore be concluded that Solignum and LBI were effective in reducing the biodegradation on Triplochiton scleroxylon (Obeche) and Isoberlina doka (Doka) woods. However, it was recommended that more research should be carried out on Aguwa extract (LBI) to test its effect on different wood species.