Land is an inevitable resource in agricultural production and its health status determines the position of agriculture in the present and future. The study investigated the ability of microbial soil enhancer to increase yield and soil nutrients, maintain soil health for sustainable and continuity in agriculture. Two (2.5ml/liter) of microbial soil enhancer was applied to the soil before planting and thereafter, 2ml/liter was applied through foliar application after every four weeks till maturity, followed by treatments with different rates of inorganic fertilizer NPK15:15:15 (20g/plant, 15g/plant, and 10g/plant). The study revealed that microbial soil enhancer gave the best-improved yield (52.67 Ton/Ha), SOM and many primary nutrients when used with 50% (10g/plant) inorganic fertilizer. Microbial soil enhancer improved and balanced the soil microorganism's community, making the soil fit for sustainable use and continuity in agriculture. It generated pro-bacteria and fungi needed for plant protection and productivity. The study also revealed that microbial soil enhancer should not be used in a virgin or fertile soil to avoid disaster outbreak. It is also good for bioremediation. It should be encouraged and supplemented with a low rate of inorganic fertilizer to increase yield, sustainability, and continuity in agriculture and also for bioremediation, to reclaim agricultural lands lost to pollution.