Low soil fertility has been a major constraint to the increased and sustainable production of maize in the savanna ecology of Ghana. Studies were conducted to compare the yield of maize from different application regimes of YARA fertilizer (Actyva, Unik-15, NPK, Sulfan, Urea and Sulphate of Ammonia) in four locations (Nyankpala, Yendi, Walewale and Damongo) within the Guinea savanna zone of Ghana. The fields were laid out in a randomized complete block design with four replications for each treatment. Data were taken on grain yield and 100 seed weight of maize, and subjected to analysis of variance, with treatment means separated at a probability of 5% using the least significant difference. There was no significant difference in maize yield between Act@125kg/ha+Act@250kg/ha and Act@250kg/ha+Act@125kg/ha. However, Act@250kg/ha+Sul@125kg/ha, though inferior to the other Actyva treatments, gave higher yield than U15@250kg/ha+SOA@125kg/ha. Soils at the different locations responded differently to the fertilization regimes. Damango tended to have similar maize yields on plots that received fertilization. In Walewale, all the Actyva treatments gave similar high yields that were greater (p<0.05) than yields of U15@250kg/ha+SOA@125kg/ha and the unfertilized plot. For Yendi, Uk15@250kg/ha+SOA@125kg/ha gave similar yield as NPK@250kg/ha+Urea@125kg/ha. In both Walewale and Yendi, Sulfan top dressed treatment gave similar high yield as the Actyva top dressed treatment., indicating superior performance of Sulfan to SOA or Urea top dressed treatments. Yield increase of up to 500% were recorded in the Actyva treatments, and attributed to the inclusion of S, B and Zn that enhanced synergy in growth promoting factors, and improvements in P and N-uptake that favoured maize growth and yield. Farmers can achieve maximum maize yield in the ecology through fertilization with Actyva formulations.