The management of Yellow Vein Mosaic Disease on Okra (Albelmoschus esculentus) is a problem in Nigeria. Studies on the Effects of Cultivar on the Incidence and Severity of Yellow Vein Mosaic Disease on Okra (Albelmechus esculentus (L.) Moench) in Wukari Local Government Area of Taraba State Nigeria, was carried out in 2021 cropping season. The experiment was conducted in a screen house, at Federal University Wukari Teaching and Research Farm. Fresh okra leaves infected with the okra vain mosaic disease were collected and pounded into jelly-like form using mortar and pistil, which were used to inoculate the experimented plant. The objectives of the study were: to determine the effect of cultivars on the incidence and severity of vein mosaic disease on okra and to determine the yield potential of these cultivars under vein mosaic disease infestation. The experiment was laid out in Complete Randomized Design (CRD). Data were taken on growth and yield parameter. The data collected were subjected to Analysis Of Variance (ANOVA) and the means were separated using Least Significant Difference (LSD) at 5% level of probability. Perkins long and Go big had the highest incidence of the disease (7.44), (5.22) respectively and Basanti 447 shows high level of resistance (2.00) to the disease. Base on the finding of this research it is recommended that farmers should adapt Basanti 447 cultivation in the study area because of its ability to resist the disease and give the expected yield potential.