The effect of oral vitamin E supplementation on the health status of liver and kidney of growing pigs during oxidative stress induced by hypothermia was studied. 27 Landrace pigs, with an average weight of 14 ±1.02 were used. Pigs were randomly assigned to three treatments (T1, T2, and T3) with 9 pigs per treatment. Each treatment had 3 replicates with 3 pigs per replicate and the study lasted for six (6) weeks. All treatments received similar diets (Pfizer Growers Marsh TM) except that T3 was administered vitamin E orally from the 4th week at the rate of 470mg/kg body weight daily. 24 hours after the last administration, T3 and T2 were immersed into a water body temperature of 120C up to their neck while same was done for T1 in temperature of 360C water. Immediately after immersion, body temperatures were taken and blood samples were collected and preserved. Results showed that Alanine Amino Transferase (ALT) had higher significant differences (P< 0.05) between T3 and T2. The T3 and T1 groups had similarities (43.66 and 44.32) in Aspartic Amino Transferase (AST) while T2 had significant differences (P<0.05) in figures. Alkaline phosphatase had significant differences (P < 0.05) in all treatments. Blood urea nitrogen (BUN), T2 had significant differences (p< 0.05) and T3 and T1 had similar values (p < 0.05). Creatinine had higher value in T2 (P < 0.01) with T1 and T3 with similar values (p < 0.01).