This study investigated the influence of indigenous books on academic performance of students of library and information science in Kwara State University, Malete. Three (3) objectives and three (3) research questions were formulated for the study. The objectives of the study were to find out the influence of familiar content expression in indigenous books; determine the influence of familiar language of expression in indigenous books; and to find out the influence of familiar illustrations in indigenous books on the academic performance of library and information science students. The researchers employed a descriptive survey design using the questionnaire as their instrument for data collection. Only 300 level students from the Department of Library and Information Science, Kwara State University, Malete were chosen to participate in the study. This is because students in 100 levels are new intakes, 200 levels are fairly new while 400 level students were on six months mandatory Student Industrial Work Experience Scheme (SIWES). They were therefore excluded from the study. Three hundred and twenty (320) copies of questionnaire were administered. All the 320 copies of the questionnaire were returned and found useable representing 100% of the distributed questionnaires. The first section of the questionnaire elicited information on students’ demographic information. The other sections elicited information on familiar content expression, language expression, and illustrations. Descriptive statistics of mean and standard deviation was used to answer the three research questions. The findings revealed that majority of the students are familiar with the content of expression in indigenous books, language of expression in indigenous books and illustrations in indigenous books in form of examples and diagrams, which simplify the book, make reading interesting and improve academic performance. The study concluded that familiar content expression, familiar language of expression and familiar illustrations in indigenous books simplify the book, enhance understanding of the contents and influence academic performance of library and information science students of Kwara State University, Malete. The study recommended that authors of indigenous books should make use of content expression that the students are familiar with. Moreover, the institution should endeavor to equip academic libraries with indigenous books that are written with the language that students are familiar with, while authors of indigenous books should adopt the use of local illustration, familiar examples and diagrams which can simplify the book, make reading interesting, and improve academic performance.