It is often believed that most plants in ethno-medical practices possess medical values, hence for thousands of years, people have resorted to medicinal plants as source of healing. The histological and haemostatic effect of aqueous extract of Lycopersicon esculentum(Tomato) on wound healing and the liver cells of male albino wistar rats was investigated using seventy (70) rats weighing 150-180g. The control group was fed normal rat feed and drinking water ad libitum while the test rats were given normal rat feed and water ad libitum in addition to administration of 1.0ml once daily of the fruit extract of Lycopersicon esculentum. Blood samples were obtained from the tails of the animals into EDTA bottles and sodium citrate bottles for analysis, later the animals were stunned and their liver extracted and placed in formalin for tissue processing and examination. The blood samples were examined for haematological and haemostatic test. Result indicate that the extract of Lycopersicon esculentum has no significant effect on haemoglobin concentration, packed cell volume and white blood cell count, while there was a significant effect on the platelet count (P<0.01), Bleeding and Clotting time (P<0.05) resulting to shortening of their time. The histological result showed no distortion in the cyto- architecture of the livercells. It could be deduced from this work that Lycopersicon esculentum contains biological principle that can affect haemostasis.