Human Immunodeficiency Virus (HIV) targets the body’s immune system making it weak to fight infections and some kinds of cancers that would have been fought in normal immune condition. Without treatment, it has a tendency of progressing to acquired immunodeficiency syndrome (AIDS).This study was undertaken to ascertain the knowledge of HIV, as well as its medical management and its impact on sexual behaviour amongst undergraduates of Chukwuemeka Odumegwu Ojukwu University (COOU) Igbariam campus. Multistage sampling method was used. Semi-structured self-administered questionnaires were distributed to two hundred and seventeen (217) Arts students of Chukewuemeka Odumegwu Ojukwu University Igbariam campus. The results showed that 209 (96.3%) students responded. Variable numbers of the respondents were mainly from the departments of Economics (10%), Education (1.4%), Law (41.6%), Political Science (25.4%), Psychology (17.2%) and Arts and Social Science (4.3%).The older age group (≥25 years) and the married/co-habiting/others were more knowledgeable of HIV than the younger respondents and the single, respectively. The differences were statistically significant, (P=0.028). However, males were significantly more knowledgeable than females (P=0.001). Also, those that did not reveal whether they had ever had sex or not, as well as those who had never had sex were more knowledgeable than those who had ever had sex (P = 0.002). This was also statistically significant. In conclusion, significantly increased number of the respondents had very good knowledge of HIV, its management and prevention. However, only 30.1% actually used condom. Also the results showed that HIV was well known even among the non-medical students.