Background: On 14 November 2022, 6,588,850 deaths from COVID-19 reported to WHO. Older age as well as pre-existing conditions, such as cardiovascular disease, chronic kidney disease, chronic lung diseases, diabetes mellitus, and hypertension predispose patients to increased risk death. Methods: This study is a retrospective case-control one that was conducted by reviewing records of all admitted COVID-19 patients in Jaber hospital in Kuwait during the period from February till May 2019. Analysis was initially carried on a series of univariate comparisons, followed by multiple logistic regression analysis.Objectives: This study aimed at highlighting some factors that could be associated with mortality of COVID-19 in admitted cases during the first wave of the disease. Results: After adjustment for the confounding effects, admitted COVID-19, older age seemed to be at higher risk of death, as patient in the age group 40-49, 50-59 and ≥ 60 years old were more prone to death as compared to those in the age group < 40 years (OR = 7.8, CIs: 3.2 – 27.0), (OR = 10.5, CIs: 4.8 – 36.5) and (OR = 18.3, CIs: 9.2 – 30.8) respectively. Patients with hypertension were 3.9 folds liable for death during hospital stay (CIs: 2.5 – 5.9), and patients with cardiac disease were 3.7 folds prone for death (CIs: 1.9 – 7.8). Also, diabetic patients and those with pulmonary disease were significantly more prone to die during their hospital stay (OR = 6.1, CIs: 2.8 – 8.2) and (OR = 5.0, CIs: 1.7 - 8.8) respectively. Patients with low level of blood oxygen on admission were 7.6 folds at risk of dying (CIs: 3.9 – 12.7) and those who needed ICU admission were 41 folds more liable to die during hospital stay (CIs: 15.1 – 69.2)Conclusions: Among the man predictors of mortality among admitted COVID-19 cases are age, comorbidities, SpO2 percentage and lymphocytic count in addition to admission to the intensive care unit.