Alhassan et al
Greener Journal of Medical Sciences Vol. 2 (1), pp. 005-011, January 2012
ISSN: 2276-7797
Research Paper
Manuscript Number: GJMS1202
Effects of aqueous avocado pear (Persea americana) seed extract on alloxan induced diabetes rats.
*A. J. Alhassan, M. S. Sule, M. K. Atiku, A. M. Wudil, H. Abubakar,
S. A. Mohammed
Department of Biochemistry, Bayero University, Kano
*Corresponding Author. Email: ajalhassan@ yahoo. com.
Abstract:
Background: world is facing explosive increase in
diabetes mellitus. It poses a serious challenge to primary
health care in developing countries, with negative
consequences on the economy. This research is aim at
evaluating the effect of Persea americana aqueous seed
extract on alloxan induced diabetes rats.
Methodology: Effects of the aqueous extract on groups
of alloxan (150mg/Kg) induced diabetic rats was
investigated. The blood sugar and body weight of the rats
was recorded at two weeks and four weeks interval, and one
week after the withdrawal of the extract. The test groups
(III, IV, and V) were treated with 400mg, 800mg and
1200mg/kg body weight of the extract for 4 weeks.
Results: A significant decrease (P<0.001) in blood
glucose were observed in all groups compared to Group II. A
significant increase in blood glucose (p<0.05) was observed
one week after withdrawal of the extract. Significant
increase in body weight was recorded in groups III, IV and V
compared to group II at P < 0.01, 0.001 and 0.05
respectively.
Conclusion: The findings may indicate anti-diabetic
effects of the extract which may be due to certain mineral
elements and phytochemicals, and increase in weight in could
be due to proper nutrient utilization probably induced by
the avocado seeds’ extract. Avocado seeds may be of
beneficial effects to diabetic patients.
Key Words: Avocado pear (Persea americana) seed,
Alloxan, Diabetes, Serum glucose.
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