Greener Journal of Medical Sciences

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Tehoua et al

Greener Journal of  Medical Sciences Vol.3 (1), pp. 032-036, January 2013

 ISSN: 2276-7797  

Research Paper

Manuscript Number: 121912335


Effect of Chronic Alcoholization toKoutoukou (a traditional spirit) on theStructure of Hepatic Tissue of Wistar Rats(Rattus norvegicus)


1Lazare Tehoua, *2André B. Konan*3Eric K. Kwadjo,4Marcel K.G. Bouafou, 5Jacques Y. Datté and 6Michel A. Offoumou


1,2,5,6Laboratory of Nutrition and Pharmacology, UFR Biosciences, Félix Houphouët-Boigny University 

22 BP 582 Abidjan 22, Cote d’Ivoire.

3Laboratory of Animal Biology and Cytology, UFR Natural Sciences, University Nangui Abrogoua, 

02 BP 801 Abidjan 02, Côte d’Ivoire

4Division of Life Sciences and Earth, Department of Sciences and Technology, Ecole Normale Supérieure (ENS), 25 BP 663 Abidjan 25, Côte d’Ivoire.


*Corresponding Author’s Email:, Tel: (+225) 05 40 97 50 / 66 10 62 53


Objective: Previous studies have shown that regular and moderate consumption of koutoukou (KTK, a traditional spirit) is associated with a negative body mass index in female rats. In addition, the consumption of this drink in the latter also has an effect on the liver. Therefore, this work is carried out in order to assess the impact of chronic use of koutoukou (KTK) on the structure of rat liver tissue. In fact, atrophy or hypertrophy of an organ, if it is not of physiological origin, may indicate pathology of the latter.
Methods: The rats were divided into 4 groups of 8 individuals (4 males and 4 females). These animals received distilled water as drinking water (Lot 1 or control) and KTK at 5 % (Lot 2), 10 % (Lot 3) and 12 % (Lot 4) in their drinking water. After 90 days of experiment, histological sections of liver were examined under an optical microscope.
Results: The chronic alcohol KTK has no impact on the structure of male rat liver. However, in females, significant changes (inclusions and lesions) were observed depending on the alcohol content of this traditional spirit.
Conclusion: Koutoukou caused in female rats changes of liver tissue, which could partly justify liver hypertrophy observed in female rats subjected to similar treatment.

Keywords: Koutoukou, Liver, Rats, Alcoholization.

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