Garba et al
Greener Journal of Medical Sciences Vol. 3 (4), pp. 121-128, May 2013.
Manuscript Number: 040313560
Effect of Leptadenia Hastata Leaf Extract on Embyo-Foetal Development in White Albino Rats
1*Garba A., 1Maurice N.A., 2Maina V.A., 3Baraya Y.S.,
1Owada A.H., 4Sa‘Adatu I., 5Gugong V.T., 1Sada A,1Agang I. and 6Hambolu S.E.
1Diagnostics and Extension Department, National Veterinary Research Institute, Vom- Nigeria.
2Dept. of Vet. Surgery and Theriogenology, Fac. Vet. Med. University of Maiduguri- Nigeria.
3Dept. of Vet. Pathology, Fac. Vet. Med. Usmanu Danfodiyo University, Sokoto.
4Dept.of Capacity Strengthening, Regulation & Standardization, Agricultural Research Council of Nigeria, Abuja.
5Dept. of General Agriculture, Nuhu Bamalli Polytechnic, Zaria- Kaduna State.
6Dept. of Vet. Public Health & Preventive Med Fac. Vet. Med, Ahmadu Bello University, Zaria.
Effect of Leptadenia hastata leaf extract on embryo-foetal development in white albino rats was investigated. A total of 25 nulliparous female and 5 male rats of approximate age of 57-60 days old were used and grouped into A-E in this study. Female rats were cohabited in a ratio of 5:1 male and allowed to acclimatize for one week. Pregnancy was determined by seeing virginal plug each morning. Pregnant females in each group A, B, C, and D where administered orally with 200mg, 300mg, 400mg and 500mg/ kg b.wt of the leaf extract of Leptadenia hastata on days 1-20 of the pregnancy. Group E served as the control and were given only normal saline per os. All the groups were sacrificed on day 20 of pregnancy and observed for changes. The results revealed that there were sites of implantation which degenerated and some foetal resorbtions seen with treated groups as compared with the control which showed normal litter. The outcome suggests abortifacient effect of the plant.
Keywords: Embryo-foetal development, Leptadenia hastata extract, White Albino rats.
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