Oyedeji et al
Greener Journal of Medical Sciences Vol. 3 (6), pp. 228-232, August 2013.
Manuscript Number: 052913648
Oxidative Stress and Lipid Profile Status in Pulmonary Tuberculosis Patients in South Western Nigeria
Samuel Oyewole Oyedeji1*, Adeyemi Adeleke Adesina2,
Olusegun Taiwo Oke3, Nihinlade Romoke Oguntuase1,
1School of Medical Laboratory Science, Chemical Pathology Department,Obafemi Awolowo University Teaching Hospital Complex, P.M.B.5538,Ile-Ife, Osun State, Nigeria.
2Chemical Pathology Department, Obafemi Awolowo University Teaching Hospital Complex, P.M.B.5538,Ile-Ife, Osun State, Nigeria.
3School of Medical Laboratory Science,Haemathology Department,Obafemi Awolowo University Teaching Hospital Complex, P.M.B.5538, Ile-Ife, Osun State, Nigeria.
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*Corresponding Author’s Email: oyedejis1214 @ yahoo. com; Phone number:+2348033822818
Malnutrition and increased free radicals generation are common findings with tuberculosis patients and these can impair their antioxidant capacity. The present study was carried out to estimate the levels of non-enzymatic antioxidants: albumin, vitamin C and E, selenium and lipid fractions in sixty–five (M = 29; F = 36) newly diagnosed (untreated) adult active tuberculosis (TB) patients and to compare them with the levels in fifty (M = 25; F = 25) apparently healthy tuberculosis free individuals of the same age group and location. Lipid fractions, MDA, albumin, vitamins C and E were estimated by standard spectrophotometric methods while selenium concentration was determined by atomic absorption spectrophotometric method. There was a significantly increased concentration of MDA (P < 0.001) in TB patients when compared with the control subjects and significantly reduced concentrations of albumin, vitamin C and E, selenium, total–cholesterol, LDL-cholesterol (P < 0.001in each case) and triglyceride (P < 0.01) were observed when the TB patients were compared with non TB infected individuals. The study showed that TB patients are predisposed to oxidative stress and reduced concentrations of lipid fractions. Highly nutritious diet fortified with antioxidants supplements is advocated for TB patients alongside chemotherapeutic management and their lipid fractions status should be monitored while managing the patients.
Keywords: Tuberculosis, oxidative stress, lipid profile, non-enzymatic antioxidants, developing country, vitamin C, vitamin E.
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