Oguwike et al
Greener Journal of Medical Sciences Vol. 7 (1), pp. 001-004, February 2017.
Manuscript Number: 020617014
Hepatotoxic Effect of Petrol and Kerosene Contaminated Diet on Albino Wistar Rats
Oguwike FN1, Onubeze DM2, Offor CC3, Asika L4,
1Dept. of Human Physiology, Faculty of Basic Medical Sciences, Chukwuemeka Odumegwu Ojukwu University Uli Campus, Anambra State.
2Department of Community Medicine, College of Medicine, Coouth Amaku Awka, Anambra State.
3Department of Med. Biochemistry, Faculty of Basic Medical Sciences Chukwuemeka Odumegwu Odumegwu Ojukwu University, Uli Campus Anambra State.
4Department of Pharmacology, Ebonyi State University Abakaliki Campus, Ebonyi State.
The consumption of Petrol or kerosene contaminated food products by people in rural areas exposed to oil drilling regions could be dangerous. Thirty male albino wistar rats with an average weight of 150-200g were selected for this study. They were grouped into five (5) groups; Group A (6 rats) served as control, Group B (6 rats) were given high dose of petrol contaminated fish, Group C(6 rats) were given low dose of petrol contaminated fish, Group D received high dose of kerosene contaminated fish ,while Group E received low dose of kerosene contaminated fish. The feeding lasted for only two weeks. At the end of 2 weeks, blood samples were collected from the animals by cardiac puncture and their serum were used to conduct liver function test.
The result from the analysis indicated that there was a significant increase in the Liver enzymes namely: Aspartate amino transferase, alkaline phosphatise, alanin transferase in the animals exposed to both high and low doses of the food contaminated with kerosene and fuel. Also there was increase in the total bilirubin of the rats exposed to high dose of the food contaminated with kerosene (p<0.05). There was a slight increase in conjugated bilirubin in the animals that received high dose of Petrol and Kerosene contaminated food. It could be deduced from this research that kerosene and Petrol contaminated fish has a toxic effect on the liver, thus causing damage or inflammation to the liver.
Key words: Petrol, kerosene, liver, aspartate transaminase, alkaline phospatase, contamination.
AWOBAJO S.A (1981). An analysis of oil spill in adent in Nigeria, 1976-1980. Proceedings of the 1981 international Seminar, Nov 9-12, Petroleum Training Institute p58-63.
BAKER F.J, SILVERTON R.E (1998). Biochemical analysis. Introduction to medical Laboratory Technology 7th Edition pg 134-139 Butterworth- Heinemann publication. Linacre House, Joordan Hill Oxford OX28 DP. 225 wildwood Avenues, Woburn MA 01801-2041.
BUSH B.M (1991). Interpretation of laboratory result for small animals clinicians. Oxford Blackwell scientific publication p25-34.
EHC20 (1982). Selected petroleum products; Environmental health criteria 20, United Nation environment programme, the international organization and world health organization. Geneva p5-8.
eLORKE D (1983). A new approach to practical acute toxicity testing. Arch. Toxicol 54: 275-278.
OKORO A.M, ANI E.J, IBU J.O, AKPOGOMOJI B.A (2006). Effect of petroleum product inhalation on some haematological indices of fuel attendants in Calabar metropolis, Nigeria. Nig. J. Physiol Sci 21: 11-25.
Call for Papers
Call for Scholarly Articles
Authors from around the world are invited to send scholary articles that suits the scope of this journal. The journal is currently open to submissions and will process and publish articles monthly in two yearly issues.
The journal is centered on quality and goes about its processes in a very timely fashion. Seasoned editors/reviewers will be consulted to review each article(s), profer quality evaluations and polish the articles with expertise before publication.
Simply send your article(s) as an e-mail attachment to firstname.lastname@example.org or email@example.com.