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Oguwike et al

Greener Journal of Medical Sciences

Vol. 10(1), pp. 1-6, 2020

ISSN: 2276-7797

Copyright ©2019, the copyright of this article is retained by the author(s)

https://gjournals.org/GJMS

 

 

 

 

 

 

Effect of Aqueous Extract of Aframomum melegueta (Alligator Pepper) on some Haematological and Biochemical Profile of Albino Wistar rat.

 

 

Oguwike F.N1; Offor C.C2; Ughachukwu P3; Chukwu L.C3; Okafor I.J4; Emenuga V5; Ezenwa S.C1

 

 

1.   Dept. of Human Physiology, Faculty of Basic Medical Sciences Uli Campus Anambra State. Nigeria.

2.   Dept. of Medical Biochemistry, Faculty of Basic Medical Sciences Uli Campus Anambra State. Nigeria.

3.   Dept. of Pharmacology, Chukwuemeka Odumegwu Ojukwu University Teaching Hospital Amaku Awka, Anambra State Nigeria.

4.   Dept. of Human Physiology, Faculty of Basic Medical Sciences Uli Campus Anambra State. Nigeria.

5.   Dept. of Medical Laboratory Sciences, University of Nigeria Enugu Campus.

 

 

ARTICLE INFO

ABSTRACT

 

Article No.: 01012001

Type: Research

 

 

In the yuletide, plant extracts, animal fluids, roots, stems and leaves have been consulted by man in his vide to overcome hunger, illness and ignorance. Alligator is one of those plants whose seeds are of research interest in this study. Its effect on some of the biochemical and hematological indices of albino Wister rats were investigated.

Twenty four (24) Albino Wistar rats weighing 120 - 150g were divided into two (2) groups. Group A (12 rats) served as control while group B (12 rats) served as the test rats. The extraction of the aqueous extract was done by cold maceration of pulverized seeds in absolute sterile water for 24 hours. The extract was filtered and concentrated in rotary evaporators at 40oC.

The central group was given normal rat feed and water. While the test rats received 1 ml of the extract. Both groups were given rat feed and water ad libitium for 28 days. At the end of the feeding, blood samples were collected from the animals by cardiac puncture and 2.0ml each were placed in anticoagulant bottles containing E DTA (Ethylene diamine tetracetic acial for hematological tests while 3.0 ml were placed in plain bottles and left to clot and the serum extracted for biochemical analysis. Results from the analysis showed a significance increase in white blood cell counts (PLO. 05) and reduced hemoglobin levels and packed cell volume (PLO .25) in the test rats, there is no effect in platelet counts, creatinin, urea and the electrolyte. It could be deduced that aqueous extract of Aframomum melegueta (Alligator pepper) has adverse effect on haemopoiesis and no effect on the kidney using the safe dose.

 

Accepted:  03/01/2020

Published: 31/01/2020

 

*Corresponding Author

Prof. (Dr.) F.N. Oguwike

E-mail: foguwike@gmail.com

Phone: 08037791363

 

Keywords:

Urea; Alligator pepper; creatinine; hemoglobin; platelet; packed cell volume

 

 

                             


 

REFERENCES

 

Alexander R.R and Griftts J.M (1993). Haematocrit in Basic Biochemical method 2nd Ed. John willey and sons inc  publication. New York P 186 – 187.

 

Baker F.J, Silverton R.E (1985) . Blood cell prediction and mastication / hematopoiesis. Introduction to Med Lab. Technology 6th education published by Butter works London P 8 306.

 

Celt et B and Katzer S (2007). Alligator Pepper, Aframomum melegueta and Ginger, Zingier officinale, reduce stored maize infestation by the maize weevil, Sitophilus zea maisn traditional African granaries. Spices in West Africa 32: 99 – 103.

 

Harbourne J.B.C (1973). Phytochemical method. Chapman and Hall, London p 269.

 

Inegbenebor U, Mill, Ebomoyi M.I, Onyia K, A, Amadi K    (2009) multiple pregnancy. In: Decherney A.H, Nathan, L. Godwin T.M,

 

Increase G.E and Evans, W.C (1996). Textbook of pharmagnosy. 14th Ed; W.B Saunders.  London PII.

 

Lorke D (1983). A new approach in practical acute toxicity testing. Arch. Toxicol    54:275 – 278.

 

Ugochukwu N. H, Babady N.E, Cobourne M, Gasset S.R (2003). The effect of Gangronema latifolium extract on serum lipid profile and oxidative stressing hepatocytes of diabetic rats. Journal of Bioscience 28 (1 ) : 1 -5 .

 


         

 

 

Cite this Article: Oguwike, FN; Offor, CC; Ughachukwu, P; Chukwu, LC; Okafor, IJ; Emenuga, V; Ezenwa, SC (2020). Effect of Aqueous Extract of Aframomum melegueta (Alligator Pepper) on some Haematological and Biochemical Profile of Albino Wistar rat. Greener Journal of Medical Sciences, 10(1): 1-6.

 



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