The aim of all medicines is to treat illnesses using diverse methods base on the cultural and beliefs systems of a people. Nso Fondom is blessed with two solid systems of therapy that is indigenous and conventional medicines. Prior to the introduction of biomedicine in Africa in general and Nso Fondom in particular in the 19th century, indigenous medicine was the only system of therapy. Conventional medicine was introduced in Nso by missionary bodies which constituted the Baptist, Catholics, the Basil missionaries and the Colonialists. Biomedicine was received in Nso with mixed feelings given that the Missionaries wanted to discard Indigenous Medicine in favor of Biomedicine. The missionaries wage a war of words against indigenous medicines wherein they described it as witchcraft, superstition, dirty and its practitioners as witch doctors. This paper argues that collaboration between Indigenous and Biomedicine is pivotal for the treatment of illnesses and improvement of the health of the masses. This is because there were illnesses that were better handled by indigenous medicines and some by conventional medicine and this called for collaboration. For the realization of this paper, both primary and secondary sources were consulted. Oral interviews were conducted and the target population was indigenous healers, nurses, medical doctors and the users of these systems of health. Archival materials were also consulted. For secondary sources, books, articles and magazines were consulted. The findings revealed that collaboration between IM and CM will improved the health of the population, prevent the outbreak of illnesses, facilitate the treatment of some illnesses and finally, collaboration will facilitate the exchanged of skills and knowledge.