This study was carried out to determine the effect of weight on moisture content and drying rate of different species of fish, a laboratory dryer was used at a constant temperature of 60oC with four different types of fish (mackerel, sardine, croaker and cat fish) cut into 50g and 100g weights. It was observed that sardine has the least moisture content for 50g sample while croaker has the least moisture content for 100g sample after drying. Croaker has fastest drying rate both for 50g and 100g, it dried faster in 50g than 100g. The Single factor Analysis of Variance shows that the higher the weight of sample test the less significant difference in the moisture content and drying weight of different species of fish.