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Greener
Journal of Human Physiology and Anatomy
Vol. 3(1), pp. 01-10, 2021
ISSN: 2354-2314
Copyright ©2021, the copyright of this article is
retained by the author(s)
https://gjournals.org/GJHPA
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Increased Heart Rate
and Steady State Among Sickle Cell Patients Seen in Sokoto, North-West Nigeria
1Michael I.
Ikedue;
2Frank B.O. Mojiminiyi; 3Muhammad A. Ndakotsu;
4Simeon A. Isezuo; 5Adamu J. Bamaiyi
1MSc, Department of Physiology. Usmanu
Danfodiyo University, Sokoto, Nigeria.
2PhD, Professor,
Department of Physiology, Usmanu Danfodiyo University, Sokoto, Nigeria.
3MBBS, FMCPath, Associate Professor of
Haematology and Consultant Haematologist Haematology Department, Usmanu
Danfodiyo University, Sokoto, Nigeria.
4MBBS, FMCP, Professor of Medicine and
Consultant Cardiologist, Internal Medicine Department, Usmanu Danfodiyo
University, Sokoto, Nigeria.
5MBBS, PhD, Senior Lecturer, Department of
Physiology, Usmanu Danfodiyo University, Sokoto, Nigeria.
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ARTICLE INFO
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ABSTRACT
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Article No.: 071021064
Type: Research
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Background: Sickle cell
anaemia (SCA) remains a major cause of morbidity and mortality among patients
homozygous for the traits. However, some patients homozygous for the disease
do not have vaso-occlusive crisis as much as others, and the reason for this
is not yet clear.
Objectives: The present study
aimed to assess haemodynamic and haematological parameters among adult SCA
patients (with crisis or in steady state) attending clinics and compared same
with normal adults.
Methods: One hundred and six consenting consecutive
subjects were recruited under the groups; Steady (n = 53) or Crisis (n = 53)
and compared the results with 40 apparently healthy genotype AA adults.
Results: We report that, the steady group, has
significantly less Packed cell volume (PCV) compared to the normal group
(27.39 ±4.36% Vs 33.44 ±1.80%, p <0.00005), but showed higher values of
PCV compared to the crisis group (27.39 ±4.36% Vs 25.67 ± 4.23%, p
<0.0422). The steady group compared to the crisis group, also demonstrated
enhanced heart rate (HR) (84.19 ± 16.53 bpm Vs 78.96 ± 15.90 bpm, p = 0.019)
and longer QTc (429.00 ± 37. 33 Vs 416.15 ±35.10, p = 0.0060).
Conclusions:
Enhanced HR, rate pressure product (RPP) and optimum systolic phase of
the cardiac cycle (QTc) in the steady state sub-group, may result in better
ventricular functions and cardiac output. Therefore, whole blood or
intravenous fluid infusion in SCA patients may improve the chronotropic and
inotropic properties of the heart, enhance tissue perfusion and oxygen
delivery that will help reduce crisis in the patients.
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Accepted: 15/07/2021
Published: 31/07/2021
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*Corresponding Author
Dr Adamu Jibril Bamaiyi
E-mail: adamu,jibril
@udusok.edu,ng; abamaiyi@ yahoo.com
Phone: +2348030925695
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Keywords: Sickle cell anaemia; Homozygous trait; Vaso-occlusive
crisis; Steady state; Heart rate; Whole blood; Intravenous infusion; Cardiac
output; Inotropic; Chronotropic
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