Greener Journal of Medical Sciences

Excellence and Timeliness


Choose Language


Jumbo and Nonye-Enyidah

Greener Journal of Medical Sciences

Vol. 11(2), pp. 246-248, 2021

ISSN: 2276-7797

Copyright ©2021, the copyright of this article is retained by the author(s)







Giant Omphalocele With Multiple Major Structural Anomalies In A Primipara At 25 Weeks Gestation: A Rare Case Report.



Awopola Ibiebelem Jumbo*; Esther Ijeoma Nonye-Enyidah



Department of Obstetrics and Gynaecology, Rivers State University Teaching Hospital, Port Harcourt, Nigeria.






Article No.:112121129

Type: Research



Background: Omphalocele is a major congenital anterior abdominal wall defect. It is often associated with other congenital anomalies that contribute to an increase in perinatal morbidity and mortality. The diagnosis could be made earlier in pregnancy with routine antenatal ultrasonography or prenatal diagnosis. Following this, termination may be offered.

Objective: To report a case of omphalocele with major structural abnormalities in a primipara at 25 weeks gestation.

Methods: The case note of the patient and how she was managed were reviewed. A relevant review of the literature on the subject was also done.

Case report: Mrs OJ was a 25year-old primipara who presented for booking at 25 weeks of gestation. she had an ultrasound scan at booking and the foetus was incidentally diagnosed as a case of omphalocele with associated major structural anomalies. She had not received folic acid in the index pregnancy and had no other risk factors. The pregnancy was terminated with misoprostol tablets following counselling. The baby was a fresh stillborn with giant omphalocele associated with gastrointestinal, renal and limb abnormalities.

Conclusion: The incidence of omphalocele could be reduced by routine use of folic acid around the time of conception and in the first trimester. However, most women in developing countries book late in pregnancy when prevention is not possible. There is a need to educate women on early booking, improve access to antenatal care and supplement food with folic acid for women in the reproductive age group.


Accepted:  23/11/2021

Published: 30/11/2021


*Corresponding Author

Awopola Ibiebelem Jumbo


Phone: +2347064901474



Giant Omphalocoele, congenital anomaly, folic acid, prenatal diagnosis.







1.    Poaty H, Pelluard F, Diallo MS, Ondima IPL, André G, Silou-Massamba JF (2019). Omphalocele: a review of common genetic etiologies. Egypt J Med Hum Genet. 20(1):1–6.

2.   Stoll C, Alembik Y, Dott B, Roth MP (2008). Omphalocele and gastroschisis and associated malformations. Am J Med Genet Part A, 146 (10): 1280-5.

3.    Verla MA, Style CC, Olutoye OO (2019). Prenatal diagnosis and management of omphalocele. Seminars in Pediatric Surgery. 28(2):84-8.

4.    Prefumo F, Izzi C. Fetal abdominal wall defects (2014). Best Pract Res Clin Obstet Gynaecol. 28(3): 391-402.

5.    Ferreira P, Reis I, Saraiva S, Gameiro M, Pina C (2020). Fetal omphalocele: case report and literature review. Ultrasound Obstet Gynecol.56 (S1): 87.

6.    Mac Bird T, Robbins JM, Druschel C, Cleves MA, Yang S, Hobbs CA (2009). Demographic and environmental risk factors for gastroschisis and omphalocele in the National Birth Defects Prevention Study. J Pediatr Surg, 44(8): 1546-51.

7.    Baerg JE, Munoz AN (2019). Long term complications and outcomes in omphalocele. Semin Pediatr Surg. 28(2):118-21.

8.    Mills JL, Carter TC, Kay DM, Browne ML, Brody LC, Liu A, et al (2012). Folate and Vitamin B12 Related Genes and Risk for Omphalocele. Hum Genet. 131(5):739.

9.    Cuba AM, Lapresa Alcalde MV, Gastaca I, Rodriguez-Martin MO, Martin Seisdedos MC, Velasco Ayuso MVR, Cebrian Muinos RC and Sayagues JM (2020). Giant isolated omphalocele: role of prenatal diagnosis in prognostic assessment and perinatal management. Case reports in Medicine, 1-6 Article ID 4578912.

10.  Skarsgard ED (2019). ‘Immediate versus staged repair of omphaloceles’. Seminars in Pediatric Surgery, 28 (2): 89-94.

11.  Rattan KN, Singh J, Jakhar R, Dalal P, Sonika P (2018). Omphalocele: 15 years experience from a single centre in a developing country. J Clin Neonatol 7: 125-129.

12.   Ayachi A, Mourali M (2016). Prenatal diagnosis of omphalocele in a woman in the first trimester of pregnancy. Pan Afri Med J 25: 187.

13.  Chen B, Chen I, Zhou Y, Mi T, Chen DY, Yin J, Xue ZF (2013). Multiple abnormalities due to a nonsense mutation in the  Alx4 gene. Genet Mol Res 12: 2771-2776.



Cite this Article: Jumbo, AI; Nonye-Enyidah, EI (2021). Giant Omphalocele With Multiple Major Structural Anomalies In A Primipara At 25 Weeks Gestation: A Rare Case Report. Greener Journal of Medical Sciences, 11(2): 246-248.


Call for Papers

Call for Scholarly Articles

Authors from around the world are invited to send scholary articles that suits the scope of this journal. The journal is currently open to submissions and will process and publish articles monthly in two yearly issues.

The journal is centered on quality and goes about its processes in a very timely fashion. Seasoned editors/reviewers will be consulted to review each article(s), profer quality evaluations and polish the articles with expertise before publication.

Simply send your article(s) as an e-mail attachment to or



Login Form

Other Journals