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Ozele and Ozele

By Ozele, KC; Ozele, N (2022).

Greener Journal of Medical Sciences

Vol. 12(1), pp. 06-24, 2022

ISSN: 2276-7797

Copyright ©2022, the copyright of this article is retained by the author(s)

https://gjournals.org/GJMS

 

 

 

 

 

Anaemia in Pregnancy and Malaria Parasitaemia in Women at Delivery after 2 Doses of Sulfadoxine-Pyrimethamine Combination in Jos.

 

 

Ozele, Kingsley Chukwuka (MBBS, FMCOG); Ozele Nonyelim (BSC, FMLSCN)

 

Consultant Special Grade 1 (Obstetrics and Gynaecology) and Head Medicine and Health Services Department, National Institute for Policy and Strategic Studies Kuru Jos Plateau State, (NVRI) Vom.1

Chief Medical Laboratory Scientist Biochemistry Division National Vertinary Research Institute (NVRI) Vom.2

 

 

ARTICLE INFO

ABSTRACT

 

Article No.: 020122010

Type: Research

Full Text: PDF, HTML, EPUB, PHP

Background: Malaria infection in pregnancy especially by Plasmodium falciparium leads to parasite sequestration in the maternal placental vascular space with consequent maternal anaemia and delivery of infant with low birth weight.

Objective: The objective of the study is to determine if significant differences exist in the occurrence of anaemia, malaria parasitaemia, placenta parasitisation and low birth weight in women at delivery after administering 2 doses of sulfadoxine-pyrimethamine combination at JUTH when compared to those women that had none or one dose of sulfadoxine-pyrimethamine.

Design: Hospital based descriptive cross sectional study.

Methodology: Consenting 171 parturients in control Group who booked for ANC at JUTH were recruited during the last four weeks of pregnancy at the antenatal clinic and a pre –structured questionnaire administered. Consenting 167 parturients in the study Group were recruited as they present in labour ward. Blood samples were collected as the women present in labour at the labour suite. Placental blood was collected after delivery of the placenta

Result: Statistically significant higher prevalence of maternal malaria parasitaemia in the none or once SP study group compared to twice SP control group. x2= 32.937, L.R= 33.660, P Value=0.000

The prevalence of anaemia before delivery was higher in the none or once SP study group compared to twice SP control group. But this was not statistically significant. X2=0.823, L.R= 0.826, P Value=0.364(Fisher exact test)

Statistically significant higher prevalence of placental parasitisation in the none or once SP study group compared to twice SP control group. X2=31.335, L.R= 34.725, P Value=0.000

Statistically significant higher prevalence of low birth weight (LBW) in the none or once SP study group compared to twice SP control group. X2=5.197, L.R= 7.120, P Value=0.029 (Fisher exact test)

Conclusion: 2 doses of SP is more effective than none or once SP in preventing malaria parasitaemia, placental parasitisation and reducing the prevalence of low birth weight in pregnancy.

 

 

Accepted:  01/02/2022

Published: 17/02/2022

 

*Corresponding Author

Dr Ozele KC MBBS FMCOG

E-mail: kingsleyozele9@ gmail.com

 

Keywords:

Anaemia, pregnany, malaria, parasataemia, sulphadozine-pyrimetamine.

 

 

 

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Cite this Article: Ozele, KC; Ozele, N (2022). Anaemia in Pregnancy and Malaria Parasitaemia in Women at Delivery after 2 Doses of Sulfadoxine-Pyrimethamine Combination in Jos. Greener Journal of Medical Sciences, 12(1): 06-24.


 

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