Ozele and Ozele
By Ozele, KC; Ozele, N (2022).
Vol. 12(1), pp. 06-24, 2022
Copyright ©2022, the copyright of this article is retained by the author(s)
Anaemia in Pregnancy and Malaria Parasitaemia in Women at Delivery after 2 Doses of Sulfadoxine-Pyrimethamine Combination in Jos.
Ozele, Kingsley Chukwuka (MBBS, FMCOG); Ozele Nonyelim (BSC, FMLSCN)
Consultant Special Grade 1 (Obstetrics and Gynaecology) and Head Medicine and Health Services Department, National Institute for Policy and Strategic Studies Kuru Jos Plateau State, (NVRI) Vom.1
Chief Medical Laboratory Scientist Biochemistry Division National Vertinary Research Institute (NVRI) Vom.2
Article No.: 020122010
Background: Malaria infection in pregnancy especially by Plasmodium falciparium leads to parasite sequestration in the maternal placental vascular space with consequent maternal anaemia and delivery of infant with low birth weight.
Objective: The objective of the study is to determine if significant differences exist in the occurrence of anaemia, malaria parasitaemia, placenta parasitisation and low birth weight in women at delivery after administering 2 doses of sulfadoxine-pyrimethamine combination at JUTH when compared to those women that had none or one dose of sulfadoxine-pyrimethamine.
Design: Hospital based descriptive cross sectional study.
Methodology: Consenting 171 parturients in control Group who booked for ANC at JUTH were recruited during the last four weeks of pregnancy at the antenatal clinic and a pre –structured questionnaire administered. Consenting 167 parturients in the study Group were recruited as they present in labour ward. Blood samples were collected as the women present in labour at the labour suite. Placental blood was collected after delivery of the placenta
Result: Statistically significant higher prevalence of maternal malaria parasitaemia in the none or once SP study group compared to twice SP control group. x2= 32.937, L.R= 33.660, P Value=0.000
The prevalence of anaemia before delivery was higher in the none or once SP study group compared to twice SP control group. But this was not statistically significant. X2=0.823, L.R= 0.826, P Value=0.364(Fisher exact test)
Statistically significant higher prevalence of placental parasitisation in the none or once SP study group compared to twice SP control group. X2=31.335, L.R= 34.725, P Value=0.000
Statistically significant higher prevalence of low birth weight (LBW) in the none or once SP study group compared to twice SP control group. X2=5.197, L.R= 7.120, P Value=0.029 (Fisher exact test)
Conclusion: 2 doses of SP is more effective than none or once SP in preventing malaria parasitaemia, placental parasitisation and reducing the prevalence of low birth weight in pregnancy.
Dr Ozele KC MBBS FMCOG
E-mail: kingsleyozele9@ gmail.com
Anaemia, pregnany, malaria, parasataemia, sulphadozine-pyrimetamine.
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Cite this Article: Ozele, KC; Ozele, N (2022). Anaemia in Pregnancy and Malaria Parasitaemia in Women at Delivery after 2 Doses of Sulfadoxine-Pyrimethamine Combination in Jos. Greener Journal of Medical Sciences, 12(1): 06-24.
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