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Etawo and Aleme
Etawo, US; Aleme, BM (2022).
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Greener Journal of Medical Sciences Vol. 12(1), pp. 103-108, 2022 ISSN: 2276-7797 Copyright ©2022, the copyright of this article is retained by the author(s) |
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Effect of Insulin Resistance on Platelet Counts in Normal, Pre-Diabetic and Diabetic Human Subjects
Etawo, U.S.1; Aleme, B.M.2
1Department of Surgery, University of Port Harcourt Teaching Hospital, Rivers State.
2Department of Biochemistry, University of Port Harcourt, Rivers State, Nigeria.
Correspondence: Aleme BM, B. Sc. Biochemistry, M. Sc Medical Biochemistry, Ph.D Medical Biochemistry, A.I.M.LS (Chemical Pathology). Assistant Director, Medical Laboratory Services (ADMLS)
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ARTICLE INFO |
ABSTRACT |
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Article No.: 030122028 Type: Research |
This study investigated the effect of insulin resistance on platelet (PLT) counts in normal, pre-diabetic and diabetic human subjects; using fasting blood sugar (FBS), glycated haemoglobin (HbA1c) and homeostasis model assessment of insulin resistance (HOMA-IR) as comparative indexes for the discussion. The study compared the PLT, FBS, HbA1c and HOMA-IR of the normal, pre-diabetics, and diabetics(three sets) so as to assess the effect of insulin resistance on platelets. One hundred and twenty adult male and female human subjects comprising forty subjects each for three sets matched for age and sex were recruited into the study based upon specified criteria. Of the sets of human subjects, twenty were males and females respectively. Group A subjects were the non-diabetic, Group B were the pre-diabetic while Group C subjects were the diabetic. Blood samples were analyzed using Randox and Accubind kits, and a Haematology analyser for the tests. The overall results revealed a significant difference at 95% level of confidence interval (p<0.05) in the parameters. PLT counts were significantly increased (p<0.05) in the pre-diabetic and diabetic groups showing values of 186.95±6.04 mL, 206.70±8.72 mL, and 229.97±11.21 mL respectively for the non-diabetics, pre-diabetics and diabetics. The FBS and HbA1c showed a significantly increasing trend with values of 4.49±0.08 mmol/l, 6.00±0.11 mmol/l, and 10.84±0.96 mmol/l for FBS; and 4.75±0.05 mmol/l, 5.73±0.08 mmol/l, and 9.74±0.47 mmol/l for HbA1c, for the non-diabetics, pre-diabetics, and diabetics respectively. All values were significantly higher (p<0.05)across the groups for both FBS and HbA1c. There was a significant difference (p<0.05) in HOMA-IR. This research revealed that insulin resistance has a significant effect on platelet counts in diabetic human subjects. |
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Accepted: 03/03/2022 Published: 25/03/2022 |
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*Corresponding Author Aleme B.M E-mail: benaleme@ yahoo.com |
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Keywords: Insulin Resistance; Platelet counts; Diabetic patient . |
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REFERENCES
1 Wilcox G. Insulin & insulin resistance. Clinical Biochemical Review, 2005. 26(2), 19–39.
2 Morigny P, Houssier M. Mouisel E. Adipocyte lipolysis & insulin resistance. Biochimie, 2016. 125, 259–266.
3 Patel TP, Rawal K, Bagchi A. Insulin resistance: an additional risk factorin the pathogenesis of cardiovascular disease in type 2 diabetes. Heart Failure Review,2016.21(1), 11-23.
4 Gastaldelli A. Role of beta-cell dysfunction, ectopic fat accumulation & insulin resistance in the pathogenesis of type 2 diabetes mellitus. Diabetes Research & Clinical Practice, 2011. 93(1), S60–S65.
5Singh B, Saxena A. Surrogate markers of insulin resistance: A review. World Journal of Diabetes Complications,2010. 1(2), 36–47.
6 Lim MH, Oh TJ, Choi K. Application of the oral minimal model to Korean subjects with normal glucose tolerance & type 2 diabetes mellitus. Diabetes & Metabolism Journal, 2016. 40, 308-317.
7Cerf ME Beta cell dysfunction & insulin resistance. Frontiers in Endocrinology, 2013. 4.
8Cheng YH, Tsao YC, Tzeng IS. Body mass index & waist circumference are better predictors of insulin resistance than total body fat percentage in middle-aged & elderly Taiwanese. Medicine (Baltimore), 2017. 96, E8126.
9 Gast KB, Tjeerdema N, Stijnen T. Insulin resistance & risk of incident cardiovascular events in adults without diabetes: meta-analysis. PLoS One, 2012. 7, e52036.
10 Xia C, Li R, Zhang S, Gong L, Ren W. Lipid accumulation product is a powerful index for recognizing insulin resistance in non-diabetic individuals. European Journal of Clinical Nutrition. European Journal of Clinical Nutrition, 2012. 66, 1035–1038.
11Zimmet P, Alberti KSJ. Global & societal implications of the diabetes epidemic. Nature,2001. 414, 782–787.
12 Park HS, Park CY, Oh SW. Prevalence of obesity & metabolic syndrome in Korean adults. Obesity Reviews, 2008. 9, 104–107.
13 Hanley AJ, Williams K, Stern MP. Homeostasis model assessment of insulin resistance in relation to the incidence of cardiovascular disease: the San Antonio Heart Study. Diabetes Care, 2002. 25, 1177-1184.
14 Bonora E, Kiechl S, Willeit J. Insulin resistance as estimated by homeostasis model assessment predicts incident symptomatic cardiovascular disease in caucasian subjects from the general population: the Bruneck study. Diabetes Care, 2007. 30(2), 318-324.
15 Rutter MK, Meigs JB, Sullivan LM. Insulin resistance, the metabolic syndrome, & incident cardiovascular events in the Framingham Offspring Study. Diabetes, 2005. 54, 3252-3257.
16McAuley KA, Williams SM, Mann JI. Diagnosing insulin resistance in the general population. Diabetes Care, 2001. 24, 460-464.
17Lee H. Methods for the assessment of insulin resistance. Journal of Korean Diabetes, 2014. 15, 7-11.
18Ascaso JF, Romero P, Real JT. Insulin resistance quantification by fasting insulin plasma values & HOMA index in a non-diabetic population. Medicina Clinica Facultad de Medicina de Barcelona, 2001. 117, 530-533.
19Ryu S, Sung KC, Chang Y. Spectrum of insulin sensitivity in the Korean population. Metabolism, 2005. 54, 1644-1651.
20Esteghamati A, Ashraf H, Esteghamati AR. Optimal threshold of homeostasis model assessment for insulin resistance in an Iranian population: the implication of metabolic syndrome to detect insulin resistance. Diabetes Research & Clinical Practice,2009. 84, 279-287.
21 Tomé MA, Botana MA, Cadarso-Suárez C. Prevalence of metabolic syndrome in Galicia (NW Spain) on four alternative definitions & association with insulin resistance. Journal of Endocrinological Investigation, 2009. 32, 505-511.
22 Gayoso-Diz P, Otero-González A, Rodriguez-Alvarez MX. Insulin resistance (HOMA-IR) cut-off values & the metabolic syndrome in a general adult population: effect of gender & age: EPIRCE cross-sectional study. BioMed Central (BMC) Endocrine Disorders, 2013. 13, 47.
23 Miller WG, Thienpont LM, Van Uytfanghe K. Toward standardization of insulin immunoassays. Clinical Chemistry, 2009. 55, 1011–1018.
24 Muniyappa R, Lee S, Chen H. Current approaches for assessing insulin sensitivity & resistance in vivo: advantages, limitations, & appropriate usage. American Journal of Physiology, Endocrinology, & Metabolism, 2008. 294, E15-E26.
25Westgard QC. Desirable biological variation database specifications; [approx. 2009. 8pp.]. Retrieved from http://www.westgard.com/biodatabase1.htm
26 Staten MA, Stern MP, Miller WG. For the Insulin Standardization Workgroup. Insulin assay standardization leading to measures of insulin sensitivity & secretion for practical clinical care. Diabetes Care, 2010. 33(1), 205-206.
27Chen Z, Caulfield MP, McPhaul MJ. Quantitative insulin analysis using liquid chromatography-tandem mass spectrometry in a high-throughput clinical laboratory. Clinical Chemistry, 2013. 59(9), 1349-1356.
28 Borai A, Livingstone C, Kaddam I. Selection of the appropriate method for the assessment of insulin resistance. BioMed Central (BMC) Medical Research Methodology, 2011. 158, 1-10.
29 Anderson DR, Sweeny DJ, Williams TA. Sampling & Sampling Distribution; Determining the Size of Sample. In: Introduction to Statistics, Concepts & Application. 2nd Edition.1991. New York: West Publishing Company.
30 Negro F. Insulin resistance & HCV: will new knowledge modify clinical management? Journal of Hepatology, 2006. 45, 514-519.
31 White DL, Ratziu V, El-Serag HB. Hepatitis C infection & risk of diabetes: a systematic review & meta-analysis. Journal of Hepatology, 2008. 49, 831-844.
32Negro F, Alaei M. Hepatitis C virus & type 2 diabetes. World Journal of Gastroenterology, 2009. 15, 1537-1547.
33 Biadgo B, Melku M, Abebe SM. Hematological indices & their correlation with fasting blood glucose level & anthropometric measurements in type 2 diabetes mellitus patients in Gondar, Northwest Ethiopia. Diabetes, Metabolic Syndrome, Obesity: Targets & Therapy, 2016. 9, 91-99.
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Cite this Article: Etawo, US; Aleme, BM (2022). Effect of Insulin Resistance on Platelet Counts in Normal, Pre-Diabetic and Diabetic Human Subjects. Greener Journal of Medical Sciences, 12(1): 103-108. |
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