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Etawo and Aleme
Etawo, US; Aleme, BM (2022).
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Greener Journal of Medical Sciences Vol. 12(1), pp. 96-102, 2022 ISSN: 2276-7797 Copyright ©2022, the copyright of this article is retained by the author(s) |
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Evaluation of Thyroid Function in Normal, Pre-Diabetic and Diabetic Subjects attending University of Port Harcourt Teaching Hospital
Etawo, U.S.1; Aleme, B.M.2
1Department of Surgery, University of Port Harcourt Teaching Hospital, Rivers State.
2Department of Biochemistry, University of Port Harcourt, Rivers State, Nigeria.
Correspondence: Aleme B. Sc. Biochemistry, M. Sc Medical Biochemistry, Ph.D Medical Biochemistry, A.I.M.LS (Chemical Pathology). Assistant Director, Medical Laboratory Services (ADMLS)
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ARTICLE INFO |
ABSTRACT |
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Article No.: 030122028 Type: Research |
This study evaluated thyroid function in normal, pre-diabetic and diabetic subjects attending University of Port Harcourt (UPTH), using glycated haemoglobin (HbA1c) and fasting blood sugar (FBS)as glycemic indices for the discussion. The study compared the thyroid function, glycated haemoglobin and fasting blood sugar of the normal, pre-diabetics, and diabetics(three sets) so as to assess thyroid hormone levels. One hundred and twenty adult male and female human subjects comprising forty subjects each for three sets matched for age and sex were recruited into the study based upon specified criteria. Of the sets of human subjects, twenty were males and females respectively. Group A subjects were the non-diabetic, Group B were the pre-diabetic while Group C subjects were the diabetic. Blood serum samples were analyzed using Randox and Accubind kits, and an auto analyser for the tests. The overall results revealed a significant difference at 95% level of confidence interval (p<0.05) in the thyroid function parameters. The FBS and HbA1c showed a significantly increasing trend with values of 4.49±0.08 mmol/l, 6.00±0.11 mmol/l, and 10.84±0.96 mmol/l for FBS; and 4.75±0.05 mmol/l, 5.73±0.08 mmol/l, and 9.74±0.47 mmol/l for HbA1c, for the non-diabetics, pre-diabetics, and diabetics respectively. All values were significantly higher (p<0.05) across the groups for both FBS and HbA1c. The thyroid function profile showed progressive decrease in values for fT3 (free triiodothyronine) and fT4 (free thyroxine) respectively for the non-diabetics, pre-diabetics, and the diabetics while the thyroid stimulating hormone (TSH) values increased significantly when compared to the normal. This study revealed that thyroid function is significantly affected in the diabetic subjects. |
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Accepted: 03/03/2022 Published: 25/03/2022 |
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*Corresponding Author Aleme B.M E-mail: benaleme@ yahoo.com |
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Keywords: Evaluation, thyroid, function, pre-diabetic, diabetic. |
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Cite this Article: Etawo, US; Aleme, BM (2022). Evaluation of Thyroid Function in Normal, Pre-Diabetic and Diabetic Subjects attending University of Port Harcourt Teaching Hospital. Greener Journal of Medical Sciences, 12(1): 96-102. |
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