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Nweke et al

by Nweke, EO; Elemuo, S; Usige, E; Offor, C; Igwedibia, P; Ifedi, I; Okeke, JC; Oguwike, FN; Oguwike RC; Oguwike, ER (2022).

Greener Journal of Medical Sciences

Vol. 12(1), pp. 91-95, 2022

ISSN: 2276-7797

Copyright ©2022, the copyright of this article is retained by the author(s)

https://gjournals.org/GJMS

 

 

 

 

 

Histological and Haemostatic Effect of Aqueous Extract of Lycopersicon esculentum (Tomatoes) On Wound Healing and Liver Cells of Male Albino Wistar Rats.

 

 

Nweke, E.O1; Elemuo, S1; Usige, E1; Offor, C2; Igwedibia, P3; Ifedi, I3; Okeke, J.C3; Oguwike, F.N3; Oguwike, R.C4;  Oguwike, E.R5

 

 

1.      Dept. of Anatomy, Faculty of Basic Medical Sciences. Chukwuemeka Odumegwu, Ojukwu University Uli campus, Anambra state.

2.      Dept. of Medical Biochemistry, Faculty of Basic Medical Laboratory Science. Chukwuemeka Odumegwu, Ojukwu University Uli campus, Anambra state.

3.      Dept. of Physiology, Faculty of Basic Medical Sciences. Chukwuemeka Odumegwu, Ojukwu University Uli campus, Anambra state.

4.      Dept. of Pharmacology, Faculty of Pharmaceutical Sciences. Chukwuemeka Odumegwu, Ojukwu University Igbariam campus, Anambra state.

5.      Dept. of Medicine and Surgery, College of Medicine. Chukwuemeka Odumegwu, Ojukwu University teaching Hospital Amaku- Awka. Anambra state Nigeria. 

 

 

ARTICLE INFO

ABSTRACT

 

Article No.:021422019

Type: Research

Full Text: PDF, HTML, EPUB, PHP

 

It is often believed that most plants in ethno-medical practices possess medical values, hence for thousands of years, people have resorted to medicinal plants as source of healing. The histological and haemostatic effect of aqueous extract of Lycopersicon esculentum (Tomato) on wound healing and the liver cells of male albino wistar rats was investigated using seventy (70) rats weighing 150-180g. The control group was fed normal rat feed and drinking water ad libitum while the test rats were given normal rat feed and water ad libitum in addition to administration of 1.0ml once daily of the fruit extract of Lycopersicon esculentum. Blood samples were obtained from the tails of the animals into EDTA bottles and sodium citrate bottles for analysis, later the animals were stunned and their liver extracted and placed in formalin for tissue processing and examination. The blood samples were examined for haematological and haemostatic test. Result indicate that the extract of Lycopersicon esculentum has no significant effect on haemoglobin concentration, packed cell volume and white blood cell count, while there was a significant effect on the platelet count (P<0.01), Bleeding and Clotting time (P<0.05) resulting to shortening of their time. The histological result showed no distortion in the cyto- architecture of the livercells. It could be deduced from this work that Lycopersicon esculentum contains biological principle that can affect haemostasis.

 

Accepted:  17/02/2022

Published: 25/03/2022

 

*Corresponding Author

Prof. F.N Oguwike

E-mail: foguwike@ gmail. com

Phone: 08037791363

 

Keywords:

Haemostasis, Lycopersicon esculentum, Histology, Prothrombin time, bleeding time, wound healing, liver cells.

 

 

 

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REFERENCES

 

1.      Baker F.J, Silverton R.E (1985). Investigation for Haemostatic abnormalities. Introduction to Medical Laboratory Technology p348. Butter worths publication, Woburn London.

 

2.      Baker F.J, Silverton R.E, Palister C.J (1998). The liver function tests. Introduction to medical laboratory technology 7th edition p130. Printed by Linacre House Jordan Hill Oxford Ox2 8DP, 225 wildwood Avenue weburn Ma 01801-2041.

 

3.      BrecherL, and Cronkite M (1950). Platelet count in Dacie J. V ed. Basic Haematological Techniques practical haematology 6th edition. Churchill Livingstone, Edinburgh London, Melbourne p43.

 

4.      Dejana E, Villa S, de Gaetano, (1982). Bleeding time in rats, a comparison of different experimental condition. Thrombo Haemostato 48: 108-111.

 

5.      Guyton A. C, (2006). Haemostasis and Blood coagulation. Textbook of Medical physiology 11th edition p457. Published by Eiseveri, a division of Reed Elsevier. Private united Sir, Pratap, Udyong captain Guar Marg. Srini was puri Delhi 110065 India.

 

6.      Harbourne J.B.C (1973). Phytochemical method. Chapman and Hall, London p273.

 

7.      Ligha A.E, Fawehimi H.B (2008). Histological observations of the wound healing properties of plant exudates of Jatropha curcas Linn. Journal of experimental and clinical Anatomy 7(1) 17-21.

 

8.      Lawrence W.T, Diegelmann R.F (1994). Growth factors in wound healing. Clin. Dermatol 12:157.

 

9.      Lorke D, (1985). A new approach on practical acute toxicity testing. Arch Toxicity 54: 275-278.

 

10.   Ogundipe .O, Anyanuw K, (2004): Tomatoe juice may cause clotting in diabetic rats with oral cancer. A newspaper repeat in Guardian newspaper Feb 24 p37.

 

11.   Oguwike F.N, (2013). Functions of the liver comprehensive Medical Physiology p98 Printed and Published in Nigeria by Ideal way Publications Nigeria. 39 Nike Road Abakpa Nike Enugu Nigeria.

 

12.   Okoli C.O, Akah P.A, Okoli A.S (2007). Potentials of leaves of Asphilia Africana (compositae) in wound care: an experimental evaluation BMC complement. Allen Med. 2007: 7: 24 Published online 2007 July 10 Doi: 10, 1186/.

 

13.   Peralta I.E, Spooner D.M (2001). Granule bound starch synthetase. Lycopersicon (mill). American Journal of Botany 88 (10) p1888-1902.

 

14.   Prockop D.J, Kivirriko K. J, (1995). Collagen molecular biology, diseases and potentials form therapy. Annual Rev. Biochem 64:403.

 

15.   Samuel G, Faraha K, Percleason E, (1992). Inventory of plants used in Traditional Medicine in Namibia. Plants of the families’ coubretacea. Journal of Ethno-pharmacology p68-70.

 

16.   Taofeeq O, Oyeniyi M.A, Tesleem A.O (2005). Mechanism of action of Jastropha gossypifolia, a stem latex as a haemostatic agent. European Journal of General Medicine. 

 

17.   Trease G.E, Evans W.C (1996). Textbook of pharmcognosy 14th ed. W.B Saunders London p14.

 

 

Cite this Article: Nweke, EO; Elemuo, S; Usige, E; Offor, C; Igwedibia, P; Ifedi, I; Okeke, JC; Oguwike, FN; Oguwike RC; Oguwike, ER (2022). Histological and Haemostatic Effect of Aqueous Extract of Lycopersicon Esculentum (Tomatoes) On Wound Healing and Liver Cells of Male Albino Wistar Rats. Greener Journal of Medical Sciences, 12(1): 91-95.

 

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